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Impact of Mepolizumab on Airway Remodeling and Inflammation in Severe Eosinophilic Asthma
An interventional, prospective study suggests that in addition to its anti-inflammatory effects, mepolizumab also may attenuate structural airway changes in severe eosinophilic asthma.
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Inspiratory Effort and Dynamic Transpulmonary Driving Pressure in Extremely Preterm Infants
A prospective, observational pilot cohort study examines the characteristics of inspiratory effort and transpulmonary driving pressure in extremely preterm infants undergoing noninvasive ventilation.
Differential Effects of Antifibrotic Treatment on Outcome Prediction via Serial Matrix Metalloproteinase-Degraded C-Reactive Protein Neoepitope Levels in Idiopathic Pulmonary Fibrosis
A bicentric prospective cohort study explores the ability of short-term trajectories of neoepitopes after initiation of antifibrotic treatment to predict therapy-related outcomes, including mortality, in patients with idiopathic pulmonary fibrosis.
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Clinician Views on Inhaler Substitution in the Veterans Health Administration
A cross-sectional survey study shows that Veterans Health Administration clinicians reported predominantly negative perceptions of the 2021 inhaler formulary change from budesonide-formoterol metered-dose inhaler to fluticasone-salmeterol dry powder inhaler.
Treatment Patterns in Patients With Incident Pulmonary Hypertension
An analysis of real-world prospective registry data indicates that there are substantial deviations in clinical practice from the current guidelines for treating incident pulmonary arterial hypertension.
Use of and Outcomes Related to Intrapleural Enzyme Therapy for Complicated Parapneumonic Effusion and Empyema in an Integrated Health System
A retrospective observational cohort study suggests that full Second Multicenter Intrapleural Sepsis Trial dosing across 21 hospitals was infrequent with a high degree of facility-level variation.
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Aspergillus fumigatus Sensitization Is Associated With High-Risk Bronchiectasis
Comparative Outcomes and Side Effects of Immunosuppressants and Tumor Necrosis Factor Inhibitors in Sarcoidosis: A Real-World Data Analysis
Clinical Outcomes in Patients With COPD With Disease Stability: Data From the Korea COPD Subgroup Study Cohort
Fear as the Second Diagnosis
Association Between Exertional Dyspnea and OSA
Each month, the journal CHEST® features the best in peer-reviewed, cutting-edge original research in the multidisciplinary specialties of chest medicine. It also houses our highly regarded clinical practice guidelines and consensus statements.
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Journal CHEST® authors, Daniel Lachant, DO, and R. James White, MD, PhD, discuss the article, "Cardiac Effort to Compare Clinic and Remote 6-Minute Walk Testing in Pulmonary Arterial Hypertension."
Moderator: Nicholas A. Kolaitis, MD, MAS
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Editor in Chief: Peter J. Mazzone, MD, MPH, FCCP
Published monthly Archived back to 1935
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Acceptance rate: 8-10% for Original Research
Time to first decision: 3 weeks
Acceptance to publication: 2 to 3 weeks to Online First, 5 months to print
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